Site not loading on iOS device when Appium version 2.4.1 is used while it is loading properly when Appium 1x is used

Site not loading when Appium version 2.4.1 or latest is used while it is loading for Appium version 2.0.0 or lower

Could you please elaborate your issue. Please add logs and snapshot, that ca helps to understand the issue. Also, which client are you using?
add appium logs if possbile or applicable in your case.